TREATMENT
- Correct underlying disorder
- Withdrawal of causative drug if feasible
- Observation with reassurance that problem is transient
- Subcutaneous mastectomy for severe, persistent cases or those with psychological concerns
- Tamoxifen (Norvadex), estrogen antagonist , has been used and Anastrozole (Arimidex), a potent and selective fourth-generation aromatase inhibitor, is also known to be effective in Tanner stage III or less gynecomastia. (Suggested by YC 10-18-1999)
Various drug regimens have been tried for gynecomastia with varying degrees of success, including the antiestrogens tamoxifen and clomiphene, the aromatase inhibitor testolactone, and danazol, a weak androgen that acts by inhibiting gonadotropin secretion and causing a fall in plasma testosterone. Treatment with dihydrotestosterone (which cannot be aromatized to estrogen) is also reported to cause significant symptomatic improvement in gynecomastia. However, no prospective controlled studies have been performed with any of these regimens, and their clinical usefulness is not established.
[Serels S; Melman A: J Urol 1998 Apr;159(4):1309 Tamoxifen use in gynecomastia
Staiman VR; Lowe FC: Urology 1997 Dec;50(6):929-33 - tamoxifen 10-30 mg/day for 1 month
McDermott MT, et al Tamoxifen therapy for painful idiopathic gynecomastia. South Med J 83: 1283, 1990
Anastrozole, an aromatase inhibitor Tx for gynecomastia reported by groups from Southwestern Med Ctr in Dallas and also from Harbor-UCLA in Torrence at Endo Society mtg at San Diego Jun. of 1999.
Plourde PV, et al.:Breast Cancer Res Treat. 1994;30(1):103-11 - Arimedex (anastrozole)
Lonning PE, et al.: "anastrozole" -Breast Cancer Res Treat. 1998;49 Suppl 1:S53-7; discussion S73-7. Review..]
Here is the study in full:
htt p://enotes.tripod.com/gynecomastia2007.pdf
Again, I'm not saying it's guaranteed just a direction to look in...
